Long-term use of Cenforce 100 (sildenafil citrate) is generally safe when taken under medical supervision, but potential risks exist. Prolonged use may lead to psychological dependence, where users feel they can't perform sexually without it. Some men may also experience chronic headaches, vision changes, nasal congestion, or hearing issues with extended use. There’s also a small risk of developing tolerance, where the drug becomes less effective over time. In rare cases, long-term use can affect heart health, especially in individuals with pre-existing cardiovascular conditions. Regular check-ups with a healthcare provider are essential to monitor side effects and ensure continued safe use.